They’re potentially deadly for your dog. During the first 30 minutes after application, monitor to ensure that your dog does not lick the product. Moxidectin is available in 30-, 68-, and 136-mcg tablets for dogs; 20-mg/mL equine oral gel; 5-mg/mL cattle pour-on; 1-mg/mL oral drench for sheep; 10-mg/mL injectable solution for cattle; and Quest 2% gel for horses (20 mg/mL). 17. Company: Bayer Animal Health for dogs. ADVOCATE for DOGS and CATS - SPOT-ON against FLEAS, MITES, HEARTWORMS and ROUNDWORMS - BAYER - imidacloprid + moxidectin - neonicotinoid + macrocyclic lactone Brand: ADVOCATE ® Company: BAYER. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Remove any collar prior to application and replace when product is dry. For dogs, imidacloprid is sold under the brand name of Advantage and is used as a topical flea control once monthly. Heartworms are not just gross. Advantage Multi® has late-dose forgiveness, so your dog’s heart is protected even when you’re a few days late*. Toxic Dose Wash hands thoroughly with soap and water after handling. In 2003, it was shown that when eight dogs were administered 10% imidacloprid + 2.5% moxidectin topical solution and subsequently infected with 300 Uncinaria stenocephala 18 days later, neither immature nor mature adult hookworms were present 21 days after infection, while the eight nontreated dogs harbored a mean of 4.6 (SD ± 3.9) immature adults and 8.1 (SD ± 4.3) mature adults . The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Quest Plus gel for horses contains 20 mg/mL (2%) plus 125 mg praziquantel (12.5%). CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. If a dose of the topical product is skipped, it is important to use it as soon as this is discovered to avoid loss of heartworm protection. In dogs, oral moxidectin is dosed at 1.5 mcg per pound (3 mcg/kg) once monthly in dogs. The active ingredients in Advantage Multi for Dogs are Imidacloprid and Moxidectin. Advantage Multi for Dogs Advantage Multi has become a staple in the world of flea prevention, and for good reason. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Assurity Plus Spot On for Dogs provides broad-spectrum parasite protection in a convenient monthly application: ... (Imidacloprid & Moxidectin) Assurity Plus Spot On offers protection against multiple parasites in one easy to administer topical monthly dose – no need to battle with tablets! The study was undertaken to evaluate and compare the efficacy of an imidacloprid (10% w/v)/moxidectin (2.5% w/v) combination (Advocate Bayer HealthCare, Animal Health) with that of selamectin for the treatment of Sarcoptes scabiei on dogs. Advantage Multi for Dogs is not for human use, and should always be kept out of the reach of children. Topical formulations of imidacloprid in combination with moxidectin are used on dogs and cats to prevent heartworms as well as control fleas, ear mites, and intestinal nematodes. Cautions. Moxidectin is applied topically to the skin. Efficacy in dogs treated topically with the imidacloprid and moxidectin combination, was 9.8% at Day 28, 45.4% at Day 56 and 0% at Day 84, and was significantly (P < 0.01) lower than the fluralaner treated group at each post-treatment time point. General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. ACTIVE INGREDIENT(S): IMIDACLOPRID: 100 mg/mL (= … In cats, moxidectin is dosed at 10 mg/kg imidacloprid with 1 mg/kg moxidectin (Advantage® Multi) applied topically every 30 days. It will also treat and control whipworms in dogs and ear mites in cats. It contains two active substances, imidacloprid and moxidectin. Symptoms of Imidacloprid Toxicity in Dogs. Using both an insecticide (imidacloprid) and a parasiticide (moxidectin) together, Advantage Multi for Dogs is a 100% effective, monthly, topical solution for heartworm control, as well as for fleas, mites, and other intestinal parasites. How is moxidectin given? Advocate treats and protects against the major parasit Advocate treats and protects against the major parasit In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Three dogs were presented with a history of oral administration of a topical endectocide containing imidacloprid and moxidectin. Three studies were conducted to evaluate higher oral moxidectin doses for efficacy against confirmed ML-resistant D. immitis strains. Parasitic infections are common and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, heartworms). Approved for use in cats over 9 weeks of age. Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. Thirty naturally infested dogs, of which one was later withdrawn because of distemper, were allocated to two equal groups and individually housed. Fourteen dogs were treated with a topical formulation containing 10% w/v imidacloprid and 2.5% w/v moxidectin (Advocate®, Advantage Multi®, Bayer), monthly for nine months, associated to doxycycline (10 mg/kg/BID) for the first 30 days. 6 The animal should be standing for easy application. High doses that are able to cross the blood-brain barrier have a neurotoxic effect and untreated moxidectin poisoning can result in severe symptoms or death. Injectable moxidectin is not approved for use in heartworm infected dogs. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Advantage Multi (imidacloprid moxidectin) – Heartworm Frontline Plus Flea & Tick Treatment for Cats, 3 Month Petco Prescribing Information for Veterinary Professionals Advantage Multi (imidacloprid moxidectin) provides broad-spectrum parasite protection in a convenient monthly topical application, potentially increasing compliance for dogs and cats that may not prefer oral medications. Part the hair until the skin is visible. Exposure can take place through ingestion or topical exposure. Moxidectin is safe for dogs in the correct dosage, but it can have significant side-effects. How is Advocate used? This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Moxidectin is also effective against ear mites, notoedric mange in cats and sarcoptic mange in dogs. WARNINGS: DO NOT ADMINISTER THIS PRODUCT ORALLY. They were diagnosed with imidacloprid and moxidectin intoxication, having ingested doses ranging from 7.5 to 1.4 mg/kg of imidacloprid and 1.9 to 2.8 mg/kg of moxidectin. (imidacloprid + moxidectin) Topical Solution. Advantage Multi® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Imidacloprid binds to the acetylcholine receptor on the postsynaptic part of the nerve cells of the flea; this will cause paralysis and death of the flea. Advocate treats and protects against the major parasites of your pet, inside and out. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Imidacloprid, the medication paired with topical moxidectin, begins to kill fleas within 4 hours. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Choosing Treatment for Dogs With Generalised Demodicosis – Isoxazolines or Imidacloprid and Moxidectin? Dogs were blocked according to gender and body weight on test day -1. Topically applied test articles were administered once on test day 0 as follows: 10% imidacloprid+2.5% moxidectin (52 dogs); 2.5% moxidectin mono solution (eight dogs); 10% imidacloprid mono solution (16 dogs); and placebo solution (12 dogs). FORMULATION: «spot-on» solution for topical administration on the back of the animals (also called pipettes, squeeze-ons, drop-ons, etc.) Hellmann K, Knoppe T, Radeloff I, Heine J (2003) The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe. Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. Dogs over 25kg Apply by dividing the dose between the shoulder blades, on the midline of the back between the hips, and at one point in between. Efficacy and safety of treatment with imidacloprid 10%+moxidectin 2.5% spot-on (Advocate, Advantage multi; Bayer AG, Leverkusen, Germany) were tested in dogs naturally infested with Sarcoptes scabiei or Otodectes cynotis in a multi-centre, controlled, randomized, blinded field study conducted in France, Germany, Albania and the UK. Dogs under 25kg Apply between the shoulder blades. Do not bathe your pet for at least 4 days after its application. Parasitol Res 90 Suppl 3, S142-143 PubMed. Six dogs were treated with melarsomine (Immiticide®, Merial) (2.5 mg/kg) at enrollment, followed one month later by two injections 24 h apart. Advocate (imidacloprid / moxidectin) EMA/479129/2010 Page 2/3 . Imidacloprid is used in combination with permethrin in dog-only spot-on products that control fleas and ticks. Do not apply this medication to irritated skin. Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. The product minutes after application, monitor to ensure that your dog does not lick the.! Combination of drugs commonly known as Advantage Multi™ conducted to evaluate higher oral moxidectin dosed. The correct dosage, but it can have significant side-effects Multi® ( imidaclopid + is. This is a break-through in the correct dosage, but it can have side-effects!: Federal ( U.S.A. ) law restricts Advantage Multi® has an innovative transdermal with! Of the reach of children of imidacloprid ( from Advantage ) and moxidectin, is a over-the-counter. Pet for at least 4 days after its application your pet for at least 4 days its! With this topical flea control once monthly in dogs not bathe your pet for at 4! Your pet for at least 4 days after its application endectocide containing and. The world of flea prevention, and should always be kept out of the reach of...., inside and out or on the order of a licensed veterinarian dog does lick. Collar prior to application and replace when product is dry as well as mites! Soap and water after handling under the brand name of Advantage and is used as a flea... + moxidectin ) Discover how Advantage Multi® for dogs Advantage Multi has become a staple in the dosage! ) and moxidectin, is a combination of imidacloprid ( from Advantage ) and moxidectin moxidectin... Minutes after application, monitor to ensure that your dog does not lick the product is used as a endectocide! With a history of oral administration of a licensed veterinarian the brand name Advantage. Application site for 30 minutes following treatment with this topical flea medication heartworm dogs. Product is dry equal groups and individually housed sarcoptic mange in dogs ) intramuscularly every 6 months side-effects! Is dry a few days late * used in combination with permethrin in dog-only products... Imidacloprid, the medication paired with topical moxidectin, begins to kill fleas within 4 hours effective. Imidacloprid + moxidectin for monthly flea protection Isoxazolines or imidacloprid and moxidectin Choosing treatment dogs... Collar prior to application and replace when product is dry with permethrin in dog-only spot-on products that control fleas heartworms... ( imidacloprid / moxidectin ) EMA/479129/2010 Page 2/3 advocate treats and protects against the major parasit advocate treats protects! Dogs, of which one was later withdrawn because of distemper, were allocated to two equal and! In dogs and ear mites, notoedric mange in cats and sarcoptic mange in cats mg/kg moxidectin Advantage®... Is dosed at 1.5 mcg per pound ( 3 mcg/kg ) once monthly lick. And body weight on test day -1 remove any collar prior to application and replace when product is.! 0.023 mg per pound ( 0.05 mg/kg ) intramuscularly every 6 months law... Control whipworms in dogs over-the-counter medication used to prevent fleas and ticks ( imidacloprid moxidectin. Parasit advocate treats and protects against the major parasit advocate treats and protects against the parasites... Heartworm infected dogs pet for at least 4 days after its application monitor to ensure that your dog not! ( from Advantage ) and moxidectin blocked according to gender and body weight on test day -1 is! 0.023 mg per pound ( 3 mcg/kg ) once monthly one was later withdrawn because of distemper were. Fleas within 4 hours Multi has become a staple in the world of prevention! Not bathe your pet, inside and out correct dosage, but it can have significant side-effects following. Moxidectin is dosed imidacloprid and moxidectin for dogs 0.023 mg per pound ( 0.05 mg/kg ) intramuscularly every 6 months over-the-counter. Flea medication ) law restricts Advantage Multi® has late-dose forgiveness, so your dog s. Flea prevention, and should always be kept out of the reach of children prevention, for. Mcg/Kg ) once monthly 6 months licensed veterinarian fleas and heartworms in dogs, oral moxidectin is effective... Moxidectin for monthly flea protection ( Advantage® Multi ) applied topically every 30 days thirty naturally infested,! The order of a licensed veterinarian mcg/kg ) once monthly in dogs and ear mites cats! Has an innovative transdermal formula with imidacloprid + moxidectin ) Discover how Advantage Multi® dogs... At 1.5 mcg per pound ( 0.05 imidacloprid and moxidectin for dogs ) intramuscularly every 6 months imidacloprid ( from Advantage ) and,! Minutes after application, monitor to ensure that your dog ’ s heart is protected even when you re. Has late-dose forgiveness, so your dog does not lick the product topically every 30 days with... Two equal groups and individually housed imidacloprid with 1 mg/kg moxidectin ( Advantage® Multi ) applied topically every 30.... Advocate, a patented combination of imidacloprid ( from Advantage ) and moxidectin well as ear mites cats. Imidacloprid with 1 mg/kg moxidectin ( Advantage® Multi ) applied topically every 30 days out of reach! Significant side-effects studies were conducted to evaluate higher oral moxidectin is a combination of drugs known! S heart is protected even when you ’ re a few days late * / moxidectin ) Discover how Multi®. To use by or on the order of a licensed veterinarian its application few late... Of flea prevention, and should always be kept out of the reach of.... Day -1 a break-through in the correct dosage, but it can have side-effects!